Caroli-Rezende, MMCaroli-RezendeVidal-Palomo, MMVidal-PalomoDominguez-Caru, MMDominguez-CaruGarcia-Arriagada, MacarenaMacarenaGarcia-Arriagada2025-04-232025-04-23201610.1055/s-0035-1562788https://sic.vriic.usach.cl/entities/publication/819d208f-03ea-49b9-b200-db900d6596aaUltrasound irradiation promoted the cyclocondensation of ?-keto esters and amidines in good to excellent yields to form sixteen highly substituted 4-pyrimidinols. Tosylation of these compounds, in another ultrasound-promoted conversion, formed 4-pyrimidyl tosylates in high yields. The use of the developed protocol as an alternative route to 4-arylpyrimidines was illustrated with three examples of the Suzuki-Miyaura cross-coupling of the prepared tosylates with phenylboronic acid. © Georg Thieme Verlag Stuttgart New York-Synthesis.en-UScondensationcross-couplingpyrimidinolstosylationultrasoundhttps://doi.org/10.1055/s-0035-1562788