Llona-Rodriguez, IILlona-RodriguezCortés, M.E.CM.E.CCortés2025-04-232025-04-23201710.1166/asl.2017.7529https://sic.vriic.usach.cl/entities/publication/2efd8278-2abc-42b3-a40b-3675e66d5f7dInstructional design is an integrated lesson planning that incorporates the different inter-dependent elements involved in the teaching-learning process. The objective of this article is to provide an updated view on how the main elements of instructional design can be considered when elaborating self-learning modules based on this approach. In addition, the article includes the results of pilot study using a self-learning module on “action potential” for bio-medical students which, in general, showed an improvement in the academic results after using this supporting teaching resource. Developing self-leaning materials following the guidelines of instructional design may be replicated for other topics included in physiology courses as well as other disciplines, and could be useful for bio-medical students to learn more effectively. © 2017 American Scientific Publishers All rights reserved.en-USAction potentialActive learningInstructional design systemSelf-learning modulehttps://doi.org/10.1166/asl.2017.7529