Reyes-Parada, MMReyes-ParadaAraya-Maturana, RamiroRamiroAraya-MaturanaCelis-Barros, CristianCristianCelis-BarrosDavid Pessoa-Mahana, CarlosCarlosDavid Pessoa-MahanaIturriaga-Vasquez, PatricioPatricioIturriaga-VasquezMella-Raipan, JaimeJaimeMella-RaipanPessoa-Mahana, HernanHernanPessoa-MahanaSaitz Barria, ClaudioClaudioSaitz BarriaUgarte Nunez, CatalinaCatalinaUgarte NunezZapata-Torres, GeraldGeraldZapata-Torres2025-04-232025-04-23201210.1248/cpb.60.632https://sic.vriic.usach.cl/entities/publication/1958a9eb-9eac-4da9-91ce-373ab985aaddA series of 3-[3-(4-aryl-1-piperazinyl)-propyl]-1H-indole derivatives (12a-h) was synthesized and evaluated for binding affinity at the human 5-hydroxytryptamine1A receptor (5-HT1AR) compounds (12b) and (12h) showed the highest 5-HT1A receptor affinity (IC 50-=15 nM). Molecular docking studies with all the compounds in a homology model of 5-HT1A showed that the main interaction anchoring the ligand in the receptor was a charge-reinforced bond between the protonated nitrogen atom (N-4) of the piperazine ring and Aspartate3.32. © 2012 The Pharmaceutical Society of Japan.en-USBindingDockingIndolylalkylarylpiperazineSynthesishttps://doi.org/10.1248/cpb.60.632